Sampling and analysis of organophosphorus nerve agents: analytical chemistry in international chemical disarmament.
Fischer E, Blum MM, Alwan WS, Forman JE.
Pure Appl. Chem. 2016 (ahead of print)

https://doi.org/10.1515/pac-2016-0902

Analytical chemistry and the Chemical Weapons Convention.
Blum MM, Mamidanna RVSM.
Anal. Bioanal. Chem. 2014; 406(21):5067-5069.

http://dx.doi.org/10.1007/s00216-014-7931-4

V-type nerve agents phosphonylate ubiquitin at biologically relevant lysine residues and induce intramolecular cyclization by an isopeptide bond.
Schmidt C, Breyer F, Blum MM, Thiermann H, Worek F, John H.
Anal. Bioanal. Chem. 2014; 406(21):5171-5185.

http://dx.doi.org/10.1007/s00216-014-7706-y

An enzyme containing microemulsion based on skin friendly oil and surfactant as decontamination medium for organo phosphates: phase behavior, structure, and enzyme activity.
Stehle R, Schulreich C, Wellert S, Gäb J, Blum MM, Kehe K, Richardt A, Lapp A, Hellweg T.
J Colloid Interface Sci. 2014; 413:127-132.

http://dx.doi.org/10.1016/j.jcis.2013.09.027

Historical perspective and modern applications of Attenuated Total Reflectance – Fourier Transform Infrared Spectroscopy (ATR-FTIR).
Blum MM, John H.
Drug Test. Anal. 2012; 4(3-4):292-308.

http://dx.doi.org/10.1002/dta.374

In vitro and in vivo efficacy of PEGylated Diisopropyl Fluorophosphatase (DFPase).
Melzer M, Heidenreich A, Dorandeu F, Gäb J, Kehe K, Thiermann H, Letzel T, Blum MM.
Drug Test. Anal. 2012; 4(3-4):262-270.

http://dx.doi.org/10.1002/dta.363

Review on UV-spectroscopic, chromatographic and electrophoretic methods for the cholinesterase reactivating antidote pralidoxime (2-PAM).
John H, Blum MM.
Drug Test. Anal. 2012; 4(3-4):179-193.

http://dx.doi.org/10.1002/dta.327

The DFPase from Loligo Vulgaris in sugar surfactant based bicontinuous microemulsions.
Wellert S, Tiersch B, Koetz J, Richardt A, Lapp A, Holderer O, Gäb J, Blum MM, Schulreich C, Stehle R, Hellweg T.
Eur. Biophys. J. 2011; 40(6):761-774.

http://dx.doi.org/10.1007/s00249-011-0689-0

Formation of pyrophosphate-like adducts from nerve agents sarin, soman and cyclosarin in phosphate buffer: Implications for analytical and toxicological investigations.
Gäb J, John H, Blum MM.
Toxicol. Lett. 2011; 200(1):34-40.

http://dx.doi.org/10.1016/j.toxlet.2010.10.011

Neutron structure and mechanistic studies of diisopropyl fluorophosphatase (DFPase).
Chen JC, Mustyakimov M, Schoenborn B, Langan P, Blum MM.
Acta Crystallogr. Sect. D Biol. Crystallogr. 2010; 66(11):1131-1138.

http://dx.doi.org/10.1107/S0907444910034013

Structural characterization of the catalytic calcium binding site in diisopropyl fluorophosphatase (DFPase) and comparison with related beta-propeller enzymes.
Blum MM, Chen JC.
Chem. Biol. Interact. 2010; 187(1-3):373-379.

http://dx.doi.org/10.1016/j.cbi.2010.02.043

X-ray structure of perdeuterated diisopropyl fluorophosphatase (DFPase): Perdeuteration of proteins for neutron diffraction.
Blum MM, Tomanicek S, John H, Hanson L, Rüterjans H, Schoenborn BP, Langan P, Chen JC.
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2010; 66(4):379-385.
http://dx.doi.org/10.1107/S1744309110004318

Stable adducts of nerve agents sarin, soman and cyclosarin with TRIS, TES and related buffer compounds – Characterization by LC-ESI-MS/MS and NMR and implications for analytical chemistry.
Gäb J, John H, Melzer M, Blum MM.
J. Chromatogr. B 2010; 878(17-18):1382-1390.
http://dx.doi.org/10.1016/j.jchromb.2010.01.043

Monitoring the hydrolysis of toxic organophosphonate nerve agents by diisopropyl fluorophosphatase (DFPase) in aqueous buffer and bicontinuous microemulsions with 1H-31P-HSQC NMR spectroscopy.
Gäb J, Melzer M, Kehe K, Wellert S, Hellweg T, Blum MM.
Anal. Bioanal. Chem. 2010;396(3):1213-1221.
http://dx.doi.org/10.1007/s00216-009-3299-2

Reversed Enantioselectivity of Diisopropyl Fluorophosphatase Against Organophohpsorus Nerve Agents by Rational Design.
Melzer M, Chen JC, Heidenreich A, Gäb J, Koller M, Kehe K, Blum MM.
J. Am. Chem. Soc. 2009;131(47):17226-17232.
http://dx.doi.org/10.1021/ja905444g

Highlighted in Nature Chemistry:
Nature Chem. 2010;2(1):4-5.
http://dx.doi.org/10.1038/nchem.487

Rapid determination of hydrogen positions and protonation states of diisopropyl fluorophosphatase by joint neutron and X-ray diffraction refinement.
Blum MM, Mustyakimov M, Rüterjans H, Kehe K, Schoenborn BP, Langan P, Chen JC.
Proc. Natl. Acad. Sci. U S A. 2009 Jan 20;106(3):713-8.
http://dx.doi.org/10.1073/pnas.0807842106

Quantification of hydrolysis of toxic organophosphates and organophosphonates by diisopropyl fluorophosphatase from Loligo vulgaris by in situ Fourier transform infrared spectroscopy.
Gäb J, Melzer M, Kehe K, Richardt A, Blum MM.
Anal. Biochem. 2009; 385(2):187-193.
http://dx.doi.org/10.1016/j.ab.2008.11.012

Inhibitory potency against human acetylcholinesterase and enzymatic hydrolysis of fluorogenic nerve agent mimics by human paraoxonase 1 and squid diisopropyl fluorophosphatase.
Blum MM, Timperley CM, Williams GR, Thiermann H, Worek F.
Biochemistry 2008; 47(18):5216-24.
http://dx.doi.org/10.1021/bi702222x

Preliminary time-of-flight neutron diffraction study on diisopropyl fluorophosphatase (DFPase) from Loligo vulgaris.
Blum MM, Koglin A, Rüterjans H, Schoenborn B, Langan P, Chen JC.
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2007; 63(1):42-5.
http://dx.doi.org/10.1107/S1744309106052924

Binding of a designed substrate analogue to diisopropyl fluorophosphatase: implications for the phosphotriesterase mechanism.
Blum MM, Löhr F, Richardt A, Rüterjans H, Chen JC.
J. Am. Chem. Soc. 2006; 128(39):12750-7.
http:/dx.doi.org/10.1021/ja061887n

Was wissen Calamari über Sarin? Enzymatische Dekontamination von Nervenkampfstoffen
Richardt A, Blum MM, Mitchell S.
Chemie in unserer Zeit. 2006; 40(4):252-259.
http://dx.doi.org/10.1002/ciuz.200600364

Conformational switches modulate protein interactions in peptide antibiotic synthetases.
Koglin A, Mofid MR, Löhr F, Schäfer B, Rogov VV, Blum MM, Mittag T, Marahiel MA, Bernhard F, Dötsch V.
Science. 2006; 312(5771):273-6.
http:/dx.doi.org/10.1126/science.1122928

Special Issues (as Guest Editor)

Analytical and Bioanalytical Chemistry
Volume 406, Issue 21 (August 2014), Pages 5067–5243

Analysis of Chemicals Relevant to the Chemical Weapons Convention.
buchcover

Drug Testing and Analysis
Volume 4, Issue 3-4 (March-April 2012), Pages 167–311

Analysis of Drugs for the Therapy of Anticholinesterase Poisoning.
buchcover

Book (as Editor and Co-Author)

Decontamination of Warfare Agents

Enzymatic methods for the Removal of B/C-Weapons

bookcover